We use large health records data to learn how drugs, diseases, and other types of expsosures could change risk of disease or change disease outcome. These studies complement our work using genomic data to understand these effects.
Genetic diseases, lifestyle, and chronic diseases can impact the development of late-onset diseases like cancer and dementias. Using genomic data, we can learn about disease mechanisms contributing to the development of these diseases of later life.
This project aims to use big experimental datasets to understand the effects of drugs on gene function in disease, and how these effects impact disease pathways.