Leveraging the shared basis of diseases

Diseases develops through successive genotypic and microenvironmental changes to the body tissue. Even for patients with similar clinical disease, the life history events contributing to its development can vary.

In this project we combine genetic, genomic, and epidemiological methods to study the processes contributing to disease incidence, such as chronic inflammation or metabolic pathologies. Our findings will illuminate disease biology and suggest personalized therapies.

Common genetic variation can alter biological processes in subtle ways that eventually lead to disease development. Resources like the UK biobank combine genetic information with data on the corresponding health states of the same people. By combining multiple types of genomic data we examine how common disease processes may impact disease development